New research suggests that people who stop using blockbuster slimming jabs like Mounjaro or Wegovy may regain shed pounds at a significantly accelerated pace than those who end conventional diet and exercise plans.
Research printed in a major medical journal points out that while obese individuals frequently drop about a fifth of their body weight while using the jabs, the weight is regained at an average rate of 0.8 kg per month once they quit.
"Users using these treatments must be aware of the danger of quick weight regain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
This pace of recovery means a return to pre-treatment mass in about 18 months.
Weighing Approaches
The study, which looked at dozens of trials involving over 9,000 of participants, compared the results of the injectable medications with conventional dieting.
Researchers note that individuals who shed pounds through diet and exercise generally see a less rapid creep back—perhaps 0.1 kg a month—once they finish.
The Reason for the Quick Rebound
Nutrition scientists suggest the mechanism of the injections explains the heightened rebound.
The injections copy a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of the hormone levels several times higher than normal might result in the system to produce less of its own natural GLP-1, and could diminish sensitivity to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this hormone supplement means appetite is no longer kept in check, making excessive eating a significant risk."
A Chronic Condition?
Health authorities recommend the injections for people with weight-linked health risks, alongside prescribed lifestyle changes.
Many experts argue that, given the high risk of weight regain, the therapy might need to be life-long.
This opinion is reinforced by drug manufacturers, who say that the findings "emphasize the long-term character of obesity," similar to managing diseases like high blood pressure.
User Experiences
Individuals who have discontinued the medication describe a intense return of appetite.
"It was like a switch activating and you become ravenous," recalled a patient.
The struggle is worsened if individuals have not established permanent dietary or behavioural modifications during treatment.
Growing Interest
Figures suggest that millions of adults in the UK have tried these injections in the last 12 months, with desire remaining high.
- Adoption is more common among females than males.
- The middle-aged age group shows the greatest usage rates.
- A large proportion access the drugs through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while the jabs are effective agents for shedding pounds, they are not a permanent solution and maintained weight loss hinges on combined lifestyle support.
